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Pharmaceutical Biotechnology (Paper No-BT-XVII)
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Masters of Science (M.Sc)
M.Sc. - Biotechnology
M.Sc. - Biotechnology : Semester- IV
Pharmaceutical Biotechnology (Paper No-BT-XVII)
Unit 4:Discovery and Development
History
History
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https://www.slideshare.net/aiswarya95thomas/drug-discovery-history-evolution-and-stages
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Pharmaceutical Biotechnology (Paper No-BT-XVII)
SYLLABUS
Unit 1:Chemotherapy
Unit 2:Chemotherapeutic Agents
Unit 3:Protein Engineering
Unit 4:Discovery and Development
Unit 5:Clinical Trials
Pharmaceutical BT - MCQs
Animal BT - MCQs
Biochemistry - MCQs
System Physiology - MCQs
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◄ Stability and activity based approaches of protein engineering
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PHARMACEUTICAL BIOTECHNOLOGY
Antimicrobial Drug
Mechanism of action of antimicrobial agents.
Mechanism of action of antimicrobial agents.
Microbial Resistance to antibiotics and antimicrobial agents (Types and Mechanism)
Types of Antibiotics
Classification of antibiotics with example
Secondary Metabolites: Types
Secondary Metabolites: Types
Secondary Metabolites:Medicinal Applications
Microbial Resistance to antibiotics and antimicrobial agents(Types and Mechanism)
Structure, Mechanism of Action and Applications of Antibacterial drug: Sulfonamides
Structure, Mechanism of Action and Applications of Antibacterial drug:Quinolones
Antiviral drug: Amantadine
Antiviral drug: Azidothymidine
Antifungal drug: Nystatin
Antifungal drug: Griseofulvin
Mechanism of action of Anticancer drugs
Drugs acting on CNS
Insulin
Blood factor VIII
Antibacterial drug:Quinolones
Antibacterial drug: Sulfonamides
Antifungal drug: Nystatin
Antifungal drug:Griseofulvin
Methods of protein sequencing: Mass spectrometry
Edman degradation
Tryptic and/or Chymotryptic Peptide Mapping
Isolation and purification of proteins
Different methods for protein engineering: Site-directed mutagenesis
Gene shuffling
Direct evolution
Mapping of protein interactions: Two hybrid
Phage display
Chemical and Physical Considerations in Protein and Peptide Stability
Stability and activity based approaches of protein engineering
Drug targeting
Rational Drug designing
Rational Drug designing
Computer Aided Drug Discovery
Computer Aided Drug Discovery
Concept of Chemoinformatics
Pharmacokinetics
Pharmacodynamics
Drug delivery systems
Liposomes
Molecular Biology of drug discovery
Combinatorial drug discovery
Phases of Clinical trials of drugs
Preclinical drug evaluation of its biological activity
Toxicity test in animals
Toxicity test in animals
ED50 and LD50 determination
ED50 and LD50 determination
Teratogenecity
Mutagenecity
Introduction to Indian, International Pharmacopoeia
Indian, International Pharmacopoeia and global regulatory guidelines.
Pharmaceutical Biotechnology
Animal Biotechnology MCQs
Biochemistry Practice MCQs
System Physiology - Practice MCQs
Drug targeting ►